当前位置: 首页 » 论文全文
←返回首页
期刊信息:
《药学服务与研究》2013年, 第13卷, 第2期, 第107-110页
标题:
N-乙酰葡萄糖胺糖基化修饰与糖尿病、阿尔茨海默病及心脏病的关系
DOI:
10.5428/pcar20130209
作者:
1. 马晨丰(第三军医大学生物波研究所药学室 重庆 400038 undermoonmcf@gmail.com)
2. 倪成伟(第三军医大学生物波研究所药学室 重庆 400038 )
3. 李騳(第三军医大学生物波研究所药学室 重庆 400038 )
4. 杨兴锐(第三军医大学生物波研究所药学室 重庆 400038 )
5. 刘艳霞(第三军医大学生物波研究所药学室 重庆 400038 liuyibin04@sina.com)
摘要:
摘要  蛋白质的O位N-乙酰葡萄糖胺(O-GlcNAc)糖基化作为一种区别于一般糖基化的翻译后修饰,会使蛋白质的功能发生多种改变。近年的研究发现,蛋白质O-GlcNAc糖基化修饰参与糖尿病、阿尔茨海默病与心脏病等多种疾病病理生理过程,因此对其研究具有积极意义。本文对蛋白质O-GlcNAc糖基化修饰与糖尿病、阿尔茨海默病和心脏病发生的关系作一综述。
欢迎阅读《药学服务与研究》!您是该文第 1502 位读者!
若需在您的论文中引用此文,请按以下格式著录参考文献:
中文著录格式 马晨丰,倪成伟,李騳,杨兴锐,刘艳霞. N-乙酰葡萄糖胺糖基化修饰与糖尿病、阿尔茨海默病及心脏病的关系[J]. 药学服务与研究. 2013; 13(2): 107-110.
英文著录格式 MA ChenFeng,NI ChengWei,LI Du,YANG XingRui,LIU YanXia. The relationship between O-GlcNAc glycosylation modification of the proteins and the occurrence of diabetes,Alzheimer’s disease and heart disease[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2013; 13(2): 107-110.
参考文献:
1. Zachara N E,Hart G W.Cell signaling,the essential role of O-GlcNAc![J].Biochim Biophys Acta,2006,1761(5-6):599-617.
2. Lubas W A,Hanover J A.Functional expression of O-linked GlcNAc transferase.Domain structure and substrate specificity[J].J Biol Chem,2000,275(15):10983-10988.
3. Xing DongQi,Gong KaiZheng,Feng WenGuang,et al.O-GlcNAc modification of NFκB p65 inhibits TNF-α-induced inflammatory mediator expression in rat aortic smooth muscle cells[J].PLoS ONE,2011,6(8):e24021.
4. Lima V V,Giachini F R,Hardy D M,et al.O-GlcNAcylation:a novel pathway contributing to the effects of endothelin in the vasculature[J].Am J Physiol Regul Integr Comp Physiol,2011,300(2):R236.
5. Ngoh G A,Watson L J,Facundo H T,et al.Augmented O-GlcNAc signaling attenuates oxidative stress and calcium overload in cardiomyocytes[J].Amino Acids,2011,40(3):895-911.
6. No¨t L G,Brocks C A,Vámhidy L,et al.Increased O-linked β-N-acetylglucosamine levels on proteins improves survival,reduces inflammation and organ damage 24 hours after trauma-hemorrhage in rats[J].Crit Care Med,2010,38(2):562-571.
7. Crawford G L,Hart G W,Whiteheart S W. Murine platelets are not regulated by O-linked beta-N-acetylglucosamine[J].Arch Biochem Biophys,2008,474(1):220-224.
8. Hanover J A,Krause M W,Love D C.The hexosamine signaling pathway:O-GlcNAc cycling in feast or famine[J].Biochim Biophys Acta,2010,1800(2):80-95.
9. McClain D A,Lubas W A,Cooksey R C,et al.Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia[J].Proc Natl Acad Sci USA,2002,99(16):10695-10699.
10. Dentin R,Hedrick S,Xie J,et al.Hepatic glucose sensing via the CREB coactivator CRTC2[J].Science,2008, 319(5868):1402-1405.
11. Housley M P,Udeshi N D,Rodgers J T,et al.PGC-1 alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose[J].J Biol Chem,2009,284(8):5148-5157.
12. Housley M P,Rodgers J T,Udeshi N D,et al.O-GlcNAc regulates FoxO activation in response to glucose[J].J Biol Chem,2008,283(24):16283-16292.
13. Parker G J,Lund K C,Taylor R P,et al.Insulin resistance of glycogen synthase mediated by O-linked N-acetyl glucosamine[J].J Biol Chem,2003,278(12):10022-10027.
14. Iqbal K,Alonso A C,Gong C X,et al.Mechanisms of neurofibrillary degeneration and the formation of neurofibrillary tangles[J].J Neural Transm Suppl,1998,53:169-180.
15. Lefebvre T,Ferreira S,Dupont-Wallois L,et al.Evidence of a balance between phosphorylation and O-GlcNAc glycosylation of tau proteins-a role in nuclear localization[J].Biochim Biophys Acta,2003,1619(2):167-176.
16. Comer F I,Hart G W.Reciprocity between O-GlcNAc and O-phosphate on the carboxyl terminal domain of RNA polymerase Ⅱ[J].Biochemistry,2001,40(26):7845-7852.
17. Yuzwa S A,Shan X,Macauley M S,et al.Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation[J].Nat Chem Biol,2012,8(4):383-399.
18. 钱慰,刘飞,朱俐,等.蛋白质O-GlcNAc糖基化修饰对tau蛋白磷酸化修饰的影响[J].生物化学与生物物理进展,2003,30(4):623-628.
19. Fülp N,Zhang ZhengHao,Marchase R B,et al.Glucosamine cardioprotection in perfused rat heart associated with increased O-linked N-acetyl glucosamine protein modification and altered p38 activation[J].Am J Physiol Heart Circ Physiol,2007,292(5):H2227-H2236.
20. Jones S P,Zachara N E,Ngoh G A,et al.Cardioprotection by N-acetyl glucosamine linkage to cellular proteins[J].Circulation,2008,117:1172-1182.
21. Ngoh G A,Watson L J,Facundo H T,et al.Non-canonical glycosyl transferase modulates post-hypoxic cardiac myocyte death and mitochondrial permeability transition[J].J Mol Cell Cardiol,2008,45(2):313-325.
22. Ngoh G A,Facundo H T,Zafir A,et al.O-GlcNAc signaling in the cardiovascular system[J].Circ Res,2010,107(2):171-185.
23. Luo B,Parker G J,Cooksey R C,et al.Chronic hexosamine flux stimulates fatty acid oxidation by activating AMP-activated protein kinase in adipocytes[J].J Biol Chem,2007,282(10):7172-7180.
24. Zachara N E,O’Donnell N,Cheung W D,et al.Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response of stress:a survival response of mammalian cells[J].J Biol Chem,2004,279(29):30133-30142.
25. Anthonisen E H,Berven L,Holm S,et al.Nuclear receptor liver X receptor is O-GlcNAc-modified in response to glucose[J].J Biol Chem,2010,285(3):1607-1615.