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期刊信息:
《药学服务与研究》2017年, 第17卷, 第5期, 第321-325页
标题:
药物性肝损伤新型生物标志物的研究进展
DOI:
10.5428/pcar20170501
作者:
1. 邵珍(上海中医药大学药物安全评价研究中心 上海 201203 [email protected])
2. 邓中平(上海中医药大学药物安全评价研究中心 上海 201203 [email protected])
摘要:
摘要  药物性肝损伤(drug induced liver injury,DILI)作为新药研发关注的重点,是药物临床前安全性评价和临床研究的难点,也是国内外肝病研究的热点。传统的肝损伤指标因灵敏性和特异性等因素,限制了其在DILI早期评价中的应用。因此,寻找及验证新的DILI生物标志物已成为近年来新药研究及临床诊断关注的焦点。本文从血清酶学、细胞因子、基因组学、蛋白质组学、代谢组学等方面,对当前具有代表性的新型DILI生物标志物进行综述,以期为DILI的预测和诊断,以及药物安全性评价提供参考。
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若需在您的论文中引用此文,请按以下格式著录参考文献:
中文著录格式 邵珍,邓中平. 药物性肝损伤新型生物标志物的研究进展[J]. 药学服务与研究. 2017; 17(5): 321-325.
英文著录格式 SHAO Zhen,DENG ZhongPing. Advances in new biomarkers of drug-induced liver injury[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2017; 17(5): 321-325.
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