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期刊信息:
《药学服务与研究》2017年, 第17卷, 第6期, 第415-418页
标题:
α-硫辛酸促进2型糖尿病老年男性患者骨形成的研究
DOI:
10.5428/pcar20170605
作者:
1. 孙菲(上海市浦东新区公利医院内分泌科 上海 200135 sunfei-top@hotmail.com)
2. 马俊花(上海市浦东新区公利医院内分泌科 上海 200135 )
3. 王菁楠(上海市浦东新区公利医院内分泌科 上海 200135 )
4. 顾明君(上海市浦东新区公利医院内分泌科 上海 200135 gumj1234@126.com)
摘要:
摘要  目的:观察α-硫辛酸对2型糖尿病患者骨代谢指标(包括骨形成指标和骨吸收指标)的影响。方法:将50例2型糖尿病老年男性患者,随机分为使用α-硫辛酸组(治疗组)和未使用α-硫辛酸组(对照组),每组各25例。治疗组用α-硫辛酸治疗14 d。收集患者用药前基本情况并检测骨形成指标(骨碱性磷酸酯酶、骨钙素、总Ⅰ型胶原氨基端延长肽)和骨吸收指标(β-Ⅰ型胶原羧基端肽降解产物),治疗结束后3个月测定两组患者的骨形成和骨吸收指标的变化并进行统计分析。结果:治疗前治疗组与对照组骨代谢指标无差异;治疗后,治疗组总Ⅰ型胶原氨基端延长肽较治疗前升高(P<0.05),且与对照组比较,差异有统计学意义(P<0.05)。结论:α-硫辛酸可提高2型糖尿病老年男性患者的总Ⅰ型胶原氨基端延长肽,促进骨形成。
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若需在您的论文中引用此文,请按以下格式著录参考文献:
中文著录格式 孙菲,马俊花,王菁楠,顾明君. α-硫辛酸促进2型糖尿病老年男性患者骨形成的研究[J]. 药学服务与研究. 2017; 17(6): 415-418.
英文著录格式 SUN Fei,MA JunHua,WANG JingNan,GU MingJun. Effects of α-thioctic acid on the promotion of bone formation in elderly men with type 2 diabetes mellitus[J]. Pharmaceutical Care and Research / yao xue fu wu yu yan jiu. 2017; 17(6): 415-418.
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